René Lacoste defeated Jean Borotra 6–4, 6–0, 6–4 in the final to win the Men's Singles tennis title at the 1926 U.S. National Championships. It was Lacoste's first U.S. Championships title and his third Grand Slam title overall. Bill Tilden was the six-time defending champion, but was upset in the quarterfinals by that year's French Championships winner Henri Cochet.