Property Value
dbo:abstract
  • Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. "Dent's disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with kidney failure, X-linked recessive hypophosphatemic rickets, and both Japanese and idiopathic low-molecular-weight proteinuria. About 60% of patients have mutations in the CLCN5 gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the OCRL1 gene (Dent 2). (en)
  • Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. "Dent's disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with kidney failure, X-linked recessive hypophosphatemic rickets, and both Japanese and idiopathic low-molecular-weight proteinuria. About 60% of patients have mutations in the CLCN5 gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the OCRL1 gene (Dent 2).Pathogenesiscaused due to loss of function mutation of Chloride CN-5 channel present on proximal convoluted tubule (en)
dbo:diseasesDB
  • 29911
dbo:geneReviewsId
  • NBK99494
dbo:geneReviewsName
  • Dent Disease (en)
dbo:icd10
  • N39.8
dbo:omim
  • 300009 (xsd:integer)
dbo:thumbnail
dbo:wikiPageEditLink
dbo:wikiPageExternalLink
dbo:wikiPageExtracted
  • 2020-04-15 06:34:21Z (xsd:date)
  • 2020-06-20 22:16:19Z (xsd:date)
  • 2020-07-15 08:14:40Z (xsd:date)
  • 2020-07-15 08:14:55Z (xsd:date)
  • 2020-09-03 12:05:22Z (xsd:date)
  • 2020-09-23 19:21:19Z (xsd:date)
  • 2020-09-23 19:23:02Z (xsd:date)
  • 2020-09-23 19:23:44Z (xsd:date)
  • 2020-09-23 19:43:49Z (xsd:date)
  • 2021-04-07 16:31:23Z (xsd:date)
  • 2021-04-07 16:31:44Z (xsd:date)
  • 2021-04-07 16:32:10Z (xsd:date)
  • 2021-04-07 16:52:17Z (xsd:date)
dbo:wikiPageHistoryLink
dbo:wikiPageID
  • 9385221 (xsd:integer)
dbo:wikiPageLength
  • 11621 (xsd:integer)
  • 11674 (xsd:integer)
  • 11689 (xsd:integer)
  • 11708 (xsd:integer)
  • 11727 (xsd:integer)
  • 11729 (xsd:integer)
  • 11749 (xsd:integer)
  • 11769 (xsd:integer)
  • 11775 (xsd:integer)
  • 11781 (xsd:integer)
  • 11790 (xsd:integer)
dbo:wikiPageModified
  • 2020-04-15 06:34:16Z (xsd:date)
  • 2020-06-20 22:16:14Z (xsd:date)
  • 2020-07-15 08:14:36Z (xsd:date)
  • 2020-07-15 08:14:51Z (xsd:date)
  • 2020-09-03 12:05:18Z (xsd:date)
  • 2020-09-23 19:21:12Z (xsd:date)
  • 2020-09-23 19:22:59Z (xsd:date)
  • 2020-09-23 19:23:40Z (xsd:date)
  • 2020-09-23 19:43:41Z (xsd:date)
  • 2021-04-07 16:31:19Z (xsd:date)
  • 2021-04-07 16:31:40Z (xsd:date)
  • 2021-04-07 16:32:01Z (xsd:date)
  • 2021-04-07 16:52:10Z (xsd:date)
dbo:wikiPageOutDegree
  • 54 (xsd:integer)
dbo:wikiPageRevisionID
  • 951050045 (xsd:integer)
  • 963631909 (xsd:integer)
  • 967782607 (xsd:integer)
  • 967782632 (xsd:integer)
  • 976521774 (xsd:integer)
  • 979957718 (xsd:integer)
  • 979957988 (xsd:integer)
  • 979958078 (xsd:integer)
  • 979961076 (xsd:integer)
  • 1016521145 (xsd:integer)
  • 1016521186 (xsd:integer)
  • 1016521240 (xsd:integer)
  • 1016524344 (xsd:integer)
dbo:wikiPageRevisionLink
dbp:wikiPageUsesTemplate
dbp:wordnet_type
dct:subject
rdf:type
rdfs:comment
  • Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. (en)
rdfs:label
  • Dent's disease (en)
owl:sameAs
foaf:depiction
foaf:isPrimaryTopicOf
foaf:name
  • Dent's disease (en)
  • Dent's disease (en)
is dbo:wikiPageRedirects of
is foaf:primaryTopic of